Article-Journal | Shuang Song | Biostatistics and Statistical Genetics | Harvard | Tsinghua

Participation bias in the estimation of heritability and genetic correlation

Wed, 31 Dec 2025 00:00:00 +0000

Partitioning and aggregating cross-tissue and tissue-specific genetic effects to identify gene-trait associations

Tue, 09 Jul 2024 00:00:00 +0000

Leveraging LD eigenvalue regression to improve the estimation of SNP heritability and confounding inflation

Fri, 30 Dec 2022 00:00:00 +0000

A data-adaptive Bayesian regression approach for polygenic risk prediction

Thu, 29 Dec 2022 00:00:00 +0000

Openness weighted association studies: leveraging personal genome information to prioritize non-coding variants

Fri, 31 Dec 2021 00:00:00 +0000

Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies

Thu, 31 Dec 2020 00:00:00 +0000

Multi-Cell-Type Openness-Weighted Association Studies for Trait-Associated Genomic Segments Prioritization

Sat, 31 Dec 2022 00:00:00 +0000

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A set of efficient methods to generate high-dimensional binary data with specified correlation structures

Thu, 30 Dec 2021 00:00:00 +0000

Law of the Iterated Logarithm and Model Selection Consistency for Independent and Dependent GLMs

Wed, 29 Dec 2021 00:00:00 +0000

The predictive value of the orientation and offset of angle α and angle κ for visual outcomes after trifocal intraocular lens implantation in an Asian cohort

Tue, 30 Dec 2025 00:00:00 +0000

The Effects of Disease‐Modifying Therapies on Optic Nerve Degeneration in Multiple Sclerosis

Mon, 29 Dec 2025 00:00:00 +0000

A robust penalized-regression-based method for multivariable Mendelian randomization using GWAS summary statistics

Sun, 31 Dec 2023 00:00:00 +0000

Cofea: correlation-based feature selection for single-cell chromatin accessibility data

Mon, 30 Dec 2024 00:00:00 +0000

Cell type annotation of single-cell chromatin accessibility data via supervised Bayesian embedding

Wed, 28 Dec 2022 00:00:00 +0000

A novel transcriptional risk score for risk prediction of complex human diseases

Tue, 28 Dec 2021 00:00:00 +0000

An unbiased kinship estimation method for genetic data analysis

Tue, 27 Dec 2022 00:00:00 +0000

Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy

Sun, 29 Dec 2024 00:00:00 +0000

Reduction of Human Mobility Matters during Early COVID-19 Outbreaks: Evidence from India, Japan and China

Sun, 26 Dec 2021 00:00:00 +0000

Scalable and accurate rare-variant association tests for whole genome sequencing time-to-event analysis in large biobanks

Fri, 27 Feb 2026 00:00:00 +0000

Significance

Rare variants (RV) identified through whole genome sequencing hold great promise for elucidating the genetic basis of disease onset, but existing methods for RV association testing are not well suited for time-to-event phenotypes. Here, we develop GATE-STAAR, a scalable and accurate framework integrating frailty modeling with functional annotations. We propose a rare-variant saddlepoint approximation to handle heavy censoring. Through comprehensive simulations and large-scale analysis of approximately 400 K UK Biobank participants, with replication in approximately 230 K All of Us participants, GATE-STAAR uncovers biologically meaningful RV associations while ensuring rigorous control of type I error. This framework is powerful to dissect the genetic architecture of disease onset and progression and advance precision medicine.

Scalable and accurate rare variant association tests for whole genome sequencing time-to-event analysis in large biobanks

Thu, 15 Jan 2026 00:00:00 +0000

Participation bias in the estimation of heritability and genetic correlation

Tue, 24 Jun 2025 00:00:00 +0000